Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar.
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2019
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Abstract
A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4',7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).
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win2019dinorcassanechemistry
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| Authors | Win, Nwet Nwet;Kyaw, May Mon;Prema, ;Ngwe, Hla;Ito, Takuya;Asakawa, Yoshinori;Okamoto, Yasuko;Tanaka, Masami;Abe, Ikuro;Morita, Hiroyuki; |
| Journal | Chemistry & biodiversity |
| Year | 2019 |
| DOI |
10.1002/cbdv.201800657
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