Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.
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2021
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Abstract
A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B. rotunda led to the isolation of nine undescribed dimeric metabolites, panduratins Q-Y. Their structures were elucidated based on NMR, MS, and ECD spectroscopic data interpretation. Panduratins Q-S and U-W exhibited potent cytotoxicity towards PANC-1 cell line with the PC values ranging from 0.8 to 6.3 μM. Panduratin W, which possessed a cyclohexenylchalcone-linked flavanone skeleton, showed the most cytotoxicity with a PC value of 0.8 μM under nutrient-deprived medium.
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nguyen2021panduratinsphytochemistry
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| Authors | Nguyen, Mai T T;Nguyen, Hai X;Dang, Phu H;Le, Tho H;Do, Truong N V;Omar, Ashraf M;Awale, Suresh;Nguyen, Nhan T; |
| Journal | Phytochemistry |
| Year | 2021 |
| DOI |
S0031-9422(20)31261-9
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