Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior.

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ID: 263801
2020
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Abstract
Low-intensity transcranial ultrasound (TUS) can non-invasively modulate human neural activity. We investigated how different fundamental sonication parameters influence the effects of TUS on the motor cortex (M1) of 16 healthy subjects by probing cortico-cortical excitability and behavior. A low-intensity 500 kHz TUS transducer was coupled to a transcranial magnetic stimulation (TMS) coil. TMS was delivered 10 ms before the end of TUS to the left M1 hotspot of the first dorsal interosseous muscle. Varying acoustic parameters (pulse repetition frequency, duty cycle, and sonication duration) on motor-evoked potential amplitude were examined. Paired-pulse measures of cortical inhibition and facilitation, and performance on a visuomotor task was also assessed. TUS safely suppressed TMS-elicited motor cortical activity, with longer sonication durations and shorter duty cycles when delivered in a blocked paradigm. TUS increased GABA-mediated short-interval intracortical inhibition and decreased reaction time on visuomotor task but not when controlled with TUS at near-somatosensory threshold intensity.
Reference Key
fomenko2020systematicelife Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fomenko, Anton;Chen, Kai-Hsiang Stanley;Nankoo, Jean-François;Saravanamuttu, James;Wang, Yanqiu;El-Baba, Mazen;Xia, Xue;Seerala, Shakthi Sanjana;Hynynen, Kullervo;Lozano, Andres M;Chen, Robert;
Journal eLife
Year 2020
DOI
10.7554/eLife.54497
URL
Keywords
neuromodulation human neuroscience transcranial magnetic stimulation brain stimulation focused ultrasound noninvasive brain stimulation transcranial ultrasound

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