Cobalt(II)[salen]-Catalyzed Selective Aerobic Oxidative Cross-Coupling between Electron-Rich Phenols and 2-Naphthols.

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ID: 263113
2019
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Abstract
A selectivity-driven catalyst design approach was adopted to address chemoselectivity issues in the oxidative coupling of phenols. This approach was utilized for developing a Co(II)[salen]-catalyzed aerobic oxidative cross-coupling of phenols in a recyclable 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) solvent. The waste-free conditions offer a sustainable entry to nonsymmetric biphenols via a mechanistic scheme that involves coupling of a liberated phenoxyl radical with a ligated 2-naphthoxyl radical.
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Authors Reiss, Hagai;Shalit, Hadas;Vershinin, Vlada;More, Nagnath Yadav;Forckosh, Hagit;Pappo, Doron;
Journal The Journal of organic chemistry
Year 2019
DOI
10.1021/acs.joc.9b00822
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