Lewis Acid Mediated Electrophilic Cyanation of 2,2'-Biphenols.

Clicks: 339
ID: 263109
2020
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Abstract
A Lewis acid mediated electrophilic cyanation of 2,2'-biphenols with a trifluoromethanesulfonyl (Tf) protecting group is reported. The cyanation reactions with less toxic, commercially available MeSCN as a cyanating reagent afforded a range of 3-cyan-2,2'-biphenols in moderate to high yields. The use of trifluoromethanesulfonyl (Tf) as a protecting group is crucial to the success of this transformation. Moreover, the cyanated products were readily transformed into various synthetically useful molecules. This protocol features high efficiency, excellent regioselectivity, and good functional group compatibility and may provide a practical tool for the synthesis and modification of biologically active compounds, catalysts, and ligands.
Reference Key
zhang2020lewisthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Wu;Yang, Wen;Zhao, Wanxiang;
Journal The Journal of organic chemistry
Year 2020
DOI
10.1021/acs.joc.0c00458
URL
Keywords
polyphenols biosensors sar studies viability spectrophotometric assay chitin inhibitors oxidase and polyphenol oxidase tyrosinase inhibitors

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