Design, Synthesis, and Anti-Proliferative Evaluation of [1,1′-biphenyl]-4-ols as Inhibitor of HUVEC Migration and Tube Formation

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ID: 263107
2012
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Abstract
Allylated biphenol neolignans contain a variety of chemopreventive entities that have been used as anti-tumor drug leads. Herein, 37 allylated biphenols were evaluated for anti-proliferative activity by the MTT assay and inhibitory effect on the migration and tube formation of HUVECs featuring anti-angiogenic properties. 3-(2-Methylbut-3-en-2-yl)-3′,5′-bis(trifluoromethyl)-[1,1′-biphenyl]-4-ol (<strong>5c</strong>) exerted an inhibitory effect on HUVECs compared to honokiol (IC<sub>50</sub> = 47.0 <em>vs.</em> 52.6 μM) and showed significant blocking effects on the proliferation of C26, Hela, K562, A549, and HepG2 (IC<sub>50</sub> = 15.0, 25.0, 21.2, 29.5, and 13.0 μM, respectively), superior to those of honokiol (IC<sub>50</sub> = 65.1, 62.0, 42.0, 75.0, and 55.4 μM, respectively). Importantly, compound <strong>5c</strong> inhibited the migration and capillary-like tube formation of HUVECs <em>in vitro</em>.
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chen2012designmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lijuan Chen, Aihua Peng, Guangcheng Wang, Jinying Chen, Xuewei Wang, Yan Ran, Liang Ma
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Journal molecules
Year 2012
DOI
DOI not found
URL
http://www.mdpi.com/1420-3049/17/7/8091
Keywords
Organic Chemistry Biology (General) Medicine (General) Medicine Dentistry

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