Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

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ID: 262477
2017
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Abstract
Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modification, and nanoparticle-based delivery systems to deliver these ON drugs are discussed.
Reference Key
sun2017enhancingmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sun, Yating;Zhao, Yarong;Zhao, Xiuting;Lee, Robert J.;Teng, Lesheng;Zhou, Chenguang;
Journal molecules
Year 2017
DOI
DOI not found
URL
https://www.mdpi.com/1420-3049/22/10/1724
Keywords
Organic Chemistry Medicine (General) Computer applications to medicine. Medical informatics environmental effects of industries and plants renewable energy sources environmental sciences psychiatry transportation engineering urbanization. city and country women. feminism history of oceania (south seas) languages and literature of eastern asia, africa, oceania the family. marriage. woman

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