Induction of lymphokine-activated killer cells against human leukemia cells in vitro

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ID: 261476
1970
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Abstract
The induction of lymphokine-activated killer (LAK) cells against fresh human leukemia cells was investigated. Two thirds of the 62 leukemias examined were susceptible to the lytic effect of allogeneic IL-2 induced LAK cells in vitro. No substantial differences could be detected between myeloid or lymphoid leukemias or with regard to the FAB subtype or the immunophenotype. Culturing mononuclear cells from peripheral blood or bonemarrow of leukemia patients with IL-2 resulted in an expansion of residual large granular lymphocytes and development of cytotoxic activity. The combination of IL-2 with IFN-gamma or the presence of tumor cells during the activation process led to an enhancement of LAK cell cytotoxicity. These results suggest that LAK cells may be useful in the treatment of leukemia.
Reference Key
teichmann1970blutinduction Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J. V. Teichmann;W. -D. Ludwig;H. Seibt-Jung;E. Thiel;J. V. Teichmann;W. -D. Ludwig;H. Seibt-Jung;E. Thiel;
Journal blut
Year 1970
DOI
doi:10.1007/BF00320242
URL
https://link.springer.com/article/10.1007/BF00320242
Keywords
oncology hematology

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