Impact of mechanical thrombectomy device on thrombus histology in acute embolic stroke.

Clicks: 239
ID: 26143
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #45 of 82 articles by views in world neurosurgery

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Although many studies have evaluated the retrieved thrombus to assess the cause of stroke after mechanical thrombectomy for acute large vessel occlusion, the results remain controversial. We investigated the hypothesis that the histology of the retrieved thrombus is enhanced by mechanical thrombectomy devices.Thrombi were collected from consecutive patients who had undergone endovascular mechanical recanalization for large intracranial vessel occlusion. The mechanical thrombectomy device used was either an aspiration catheter or a stent retriever. The hematoxylin- and eosin-stained specimens were quantitatively analyzed with respect to the relative fractions of the main constituents (erythrocytes and fibrin). Clinical and radiological findings were also evaluated.Of 65 patients, an aspiration catheter was used in 27 and a stent retriever was used in 38. The presence of a preoperative susceptibility vessel sign on magnetic resonance imaging was not correlated with the percentage of erythrocytes. The thrombus cross-sectional area was larger in the aspiration group than stent group (P < 0.01). Conversely, the percentage of the fibrin component was higher in the stent group (P < 0.001). Interestingly, preoperative intravenous administration of recombinant tissue plasminogen activator reduced the thrombus cross-sectional area with a trend of increased percentage of fibrin and reduced percentage of erythrocyte in the stent group.The histological differences between the retrieved thrombi are enhanced by mechanical thrombectomy devices. Stent retrievers may crush the thrombus, which may have a synergistic effect with recombinant tissue plasminogen activator. The histology of the retrieved thrombi might be different from the original thrombi.
Reference Key
horie2019impactworld Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Horie, Nobutaka;Shobayashi, Kazuya;Morofuji, Yoichi;Sadakata, Eisaku;Iki, Yusuke;Matsunaga, Yuki;Kanamoto, Tadashi;Tateishi, Yohei;Izumo, Tsuyoshi;Anda, Takeo;Morikawa, Minoru;Tsujino, Akira;Matsuo, Takayuki;
Journal world neurosurgery
Year 2019
DOI
S1878-8750(19)32286-7
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.