Antimicrobial potential of alkalophilic micromycetes Emericellopsis alkalina

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ID: 261405
2017
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Abstract
The ability of alkalophilic micromycetes of the Emericellopsis alkalinа to produce antimicrobial peptides has been studied. Evaluation of the spectrum and the yield of antibiotic compounds has allowed us to choose a promising producer of peptide antimycotics, Emericellopsis аlkalinа А118. The producer exhibits antifungal activity against conditionally pathogenic yeast and mold fungi, i.e., Candida аlbicans, Aspergillus niger, and A. fumigatus. The group of homologous active compounds isolated by the set of identified structural features (molecular weight, the ratio of the absorption at certain wavelengths, and the absence of initiation of Edman sequencing) may be attributed to peptaibols, which are a group of nonribosomal membrane-active antimicrobial peptides with a specificity of action primarily against fungi-micromycetes.
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Authors A. A. Baranova;M. L. Georgieva;E. N. Bilanenko;Ya. A. Andreev;E. A. Rogozhin;V. S. Sadykova;A. A. Baranova;M. L. Georgieva;E. N. Bilanenko;Ya. A. Andreev;E. A. Rogozhin;V. S. Sadykova;
Journal applied biochemistry and microbiology
Year 2017
DOI
doi:10.1134/S0003683817060035
URL
https://link.springer.com/article/10.1134/S0003683817060035
Keywords
Microbiology biochemistry medical microbiology general

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