Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men

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ID: 261240
1970
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Abstract
The pathophysiology of HIV associated immune thrombocytopenia (HIV-ITP) and its response to AZT was investigated. Using autologous 111Indium-labelled platelets, platelet kinetic were analysed in two patient groups. Group 1 (untreated) was comprised of 13 patients with HIV-ITP. Group 2 (AZT) was comprised of 6 patients with a history of HIV-ITP prior to starting AZT. These patients were studied following a rise in their platelet count on AZT. Platelet survivals in both groups were shortened compared to controls, however there was no significant difference between the 2 groups. However platelet turnover rates were significantly depressed in Group 1 compared to Group 2 (P<0.05) and control values (P<0.05). The platelet count correlated with platelet turnover in Group 1 but not in AZT treated patients. Thus patients with HIV-ITP appear to have both shortened survivals and suppressed platelet production. The mechanism of the latter is unknown, but the increased turnover rate seen with AZT suggests it is a direct or indirect effect of the HIV virus.
Reference Key
ballem1970blutpathophysiology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors P. J. Ballem;A. Belzberg;D. Devine;P. Doubroff;C. Mikulash;B. Spurston;H. Chambers;C. Sartori;N. Buskard;P. J. Ballem;A. Belzberg;D. Devine;P. Doubroff;C. Mikulash;B. Spurston;H. Chambers;C. Sartori;N. Buskard;
Journal blut
Year 1970
DOI
doi:10.1007/BF00320260
URL
https://link.springer.com/article/10.1007/BF00320260
Keywords
oncology hematology

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