Neonatal autoimmune thrombocytopenia: role of high-dose intravenous immunoglobulin G therapy
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ID: 261224
1970
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Abstract
High-dose intravenous immunoglobulin G (IVIgG) therapy results in a rapid reversal of thrombocytopenia in over 80% of children with acute immune thrombocytopenic purpura (ITP). Comparable results were observed in eleven infants with an analogous condition, neonatal autoimmune thrombocytopenia (NATP), who received IVIgG (2 g/kg body weight) administered alone (n=6) or in combination with steroids (n=5). The median platelet count pre-IVIgG therapy was 25×109/l (range 5 to 74×109/l). The overall response rate to IVIgG therapy, administered alone or in combination with steroids was 75% (12 of 16 treatment episodes). A good response to therapy was defined as an increase in the platelet count to ⪖ 50×109/l and at least twice the pre-treatment value at 48 h after completion of the IVIgG infusion. The rapid and generally excellent response to IVIgG therapy in infants with NATP suggests that this treatment approach should be considered as first-line therapy for severely thrombocytopenic infants with this self-limiting but potentially serious disorder.
| Reference Key |
blanchette1970blutneonatal
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|---|---|
| Authors | Victor Blanchette;Maureen Andrew;Max Perlman;Emily Ling;Ami Ballin;Victor Blanchette;Maureen Andrew;Max Perlman;Emily Ling;Ami Ballin; |
| Journal | blut |
| Year | 1970 |
| DOI |
doi:10.1007/BF00320267
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| URL | |
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