Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials

Clicks: 216
ID: 261183
2018
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Many efforts are continuously devoted to the construction of hybrid biomaterials for specific applications, by immobilizing enzymes on different types of surfaces and/or nanomaterials. In addition, advances in computational, molecular and structural biology have led to a variety of strategies for designing and engineering artificial enzymes with defined catalytic properties. Here, we report the conjugation of an artificial heme enzyme (MIMO) with lipoic acid (LA) as a building block for the development of gold-based biomaterials. We show that the artificial MIMO@LA can be successfully conjugated to gold nanoparticles or immobilized onto gold electrode surfaces, displaying quasi-reversible redox properties and peroxidase activity. The results of this work open interesting perspectives toward the development of new totally-synthetic catalytic biomaterials for application in biotechnology and biomedicine, expanding the range of the biomolecular component aside from traditional native enzymes.
Reference Key
zambrano2018internationalartificial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gerardo Zambrano;Emmanuel Ruggiero;Anna Malafronte;Marco Chino;Ornella Maglio;Vincenzo Pavone;Flavia Nastri;Angela Lombardi;Zambrano, Gerardo;Ruggiero, Emmanuel;Malafronte, Anna;Chino, Marco;Maglio, Ornella;Pavone, Vincenzo;Nastri, Flavia;Lombardi, Angela;
Journal International journal of molecular sciences
Year 2018
DOI
10.3390/ijms19102896
URL
https://dx.doi.org/10.3390/ijms19102896
Keywords
gold nanoparticles catalytic activity peroxidases artificial enzymes immobilization strategies functional biomaterials

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.