A Computational Analysis of the Factors Governing the Dynamics of α7 nAChR and Its Homologs.

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ID: 261030
2020
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Abstract
The α7 nicotinic acetylcholine receptor is a homopentameric ion channel from the Cys-loop receptor superfamily targeted for psychiatric indications and inflammatory pain. Molecular dynamics studies of the receptor have focused on residue mobility and global conformational changes to address receptor function. However, a comparative analysis of α7 with its homologs that cannot trigger channel opening has not been made so far. To identify the residues involved in α7 activation, we ran triplicate 500-ns molecular dynamics simulations with an α7 extracellular domain homology model and two acetylcholine-binding protein homologs. We tested the effect of ligand binding and amino acid sequence on the structure and dynamics of the three proteins. We found that mobile regions identified based on root mean-square deviation and root mean-square fluctuation values are not always consistent among the individual α7 extracellular domain simulations. Comparison of the replica-average properties of the three proteins based on dynamic cross-correlation maps showed that ligand binding affects the coupling between the C-loop and the Cys-loop, vestibular loop, and β1-β2 loops. In addition, the main-immunogenic-region-like domain of α7 went through correlated motions with multiple domains of the receptor. These correlated motions were absent or diminished in α7 homologs, suggesting a unique role in α7 activation.
Reference Key
gulsevin2020abiophysical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gulsevin, Alican;Meiler, Jens;Horenstein, Nicole A;
Journal Biophysical journal
Year 2020
DOI
S0006-3495(20)30715-3
URL
Keywords
dermatology semantic segmentation in vivo segmentation melanocytic lesion reflectance confocal microscopy

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