Prediction of compound synergism from chemical-genetic interactions by machine learning
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2015
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Abstract
The structure of genetic interaction networks predicts that, analogous to synthetic lethal interactions between non-essential genes, combinations of compounds with latent activities may exhibit potent synergism. To test this hypothesis, we generated a ...
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tyers2015cellprediction
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| Authors | Jan Wildenhain, Michaela Spitzer, Sonam Dolma, David Bellows, Nick Jarvik, Rachel White, Marcia Roy, Emma Griffiths, Gerard D. Wright, Mike Tyers;Jan Wildenhain;Michaela Spitzer;Sonam Dolma;David Bellows;Nick Jarvik;Rachel White;Marcia Roy;Emma Griffiths;Gerard D. Wright;Mike Tyers; |
| Journal | cell systems |
| Year | 2015 |
| DOI |
10.1016/j.cels.2015.12.003
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