Prediction of compound synergism from chemical-genetic interactions by machine learning

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ID: 260954
2015
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Abstract
The structure of genetic interaction networks predicts that, analogous to synthetic lethal interactions between non-essential genes, combinations of compounds with latent activities may exhibit potent synergism. To test this hypothesis, we generated a ...
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tyers2015cellprediction Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jan Wildenhain, Michaela Spitzer, Sonam Dolma, David Bellows, Nick Jarvik, Rachel White, Marcia Roy, Emma Griffiths, Gerard D. Wright, Mike Tyers;Jan Wildenhain;Michaela Spitzer;Sonam Dolma;David Bellows;Nick Jarvik;Rachel White;Marcia Roy;Emma Griffiths;Gerard D. Wright;Mike Tyers;
Journal cell systems
Year 2015
DOI
10.1016/j.cels.2015.12.003
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