Recent trends in platelet antigen/antibody detection
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ID: 260780
1970
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Abstract
The detection of platelet antigens and platelet antibodies has always been difficult. Recent technical achievements are due to the availability of more specific and sensitive reagents (i.e. F(ab)2 fragments; higher specific activity of labels; monoclonal antibodies directed against platelet membrane constituents etc.) and the application of advanced immunological assays to platelet immunology (i.e. blotting assays, “capture”-ELISA's and radioimmunoprecipitation in conjunction with SDS polyacrylamide gel electrophoresis). These techniques have permitted the definition and immunochemical characterization of new platelet allo- and autoantigens, have assisted in clinical diagnosis and promoted our understanding of pathogenic mechanisms. Illustrative examples are presented and discussed.
| Reference Key |
mueller-eckhardt1970blutrecent
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|---|---|
| Authors | C. Mueller-Eckhardt;V. Kiefel;S. Santoso;C. Mueller-Eckhardt;V. Kiefel;S. Santoso; |
| Journal | blut |
| Year | 1970 |
| DOI |
doi:10.1007/BF00320246
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| URL | |
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