Prediction of the effect of immunoglobulin therapy in ITP

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ID: 260764
1970
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Abstract
The correlation between the response to high-dose immunoglobulin therapy (IVIg) and the sequestration pattern of Indium-labeled platelets (In-PLT) in the body was studied in 9 patients with chronic idiopathic thrombocytopenic purpura (ITP). Patients that has prominent platelet sequestration in the spleen responded to IVIg. In these patients, splenic sequestration decreased by 20–30% after IVIg without significant changes in hepatic sequestration. This finding suggests that the blocking of splenic Fc receptors with immunoglobulin minimized the destruction of sensitized platelets. However, patients who had almost equal platelet sequestration in the liver and spleen did not respond to IVIg. In these patients, hepatic sequestration decreased after IVIg, whereas splenic sequestration increased. Thus, it appears that estimating the platelet sequestration pattern using In-PLT is useful for predicting the effects of IVIg.
Reference Key
kawasugi1970blutprediction Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors K. Kawasugi;J. Matsuda;T. Abe;K. Kawasugi;J. Matsuda;T. Abe;
Journal blut
Year 1970
DOI
doi:10.1007/BF00320255
URL
https://link.springer.com/article/10.1007/BF00320255
Keywords
oncology hematology

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