Human monoclonal autoantibodies to characterize platelet antigens in immune-mediated thrombocytopenia

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ID: 260722
1970
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Abstract
Idiopathic thrombocytopenic purpura is characterized by antiplatelet antibodies which mediate the rapid destruction of these cells by the reticuloendothelial cell system. Low serum titers of autoantibodies and the polyclonal nature of human serum make it difficult to identify platelet target antigens with plasma antibodies. To circumvent these problems, we have utilized the techniques of EBV transformation and somatic cell hybridization in order to isolate human monoclonal antibodies from patients with ITP. In this paper we describe the use of human monoclonal autoantibodies to characterize an activation specific antigen on GPIIIa and an autoantigen on the GPIb complex. Ultimately, we hope to determine whether these autoantibodies emerge from a pool of naturally occurring antibodies to activation or senescence antigens, or are triggered by environmental agents such as bacteria or virus, which are comprised of antigens similar to those found on the platelet membrane.
Reference Key
nugent1970bluthuman Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Diane Jean Nugent;Diane Jean Nugent;
Journal blut
Year 1970
DOI
doi:10.1007/BF00320249
URL
https://link.springer.com/article/10.1007/BF00320249
Keywords
oncology hematology

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