Cellular changes during the infusion of high dose intravenous immunoglobulin

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ID: 260716
1970
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Abstract
With the ever widening group of autoimmune conditions that are beneficially affected by infusions of high dose immunoglobulin the possible mechanisms of action of such therapy appear increasingly complex. Fc mediated blockade of the mononuclear phagocyte system is an acknowledged early effect. This is, however, accompanied by a decrease of neutrophil counts which suggests that IgG binding to the neutrophil may be a mechanism of action. The decrease of neutrophil counts is transient but in immune thrombocytopenia is inversely proportional to the platelet response observed. In parallel to the effect on the neutrophil there are changes in the lymphocyte subsets with reversal of the T helper/suppressor ratio and alterations in the individual cellular constituents of each subset that correlate with the clinical response. The observed changes in B cell numbers and function suggest that T dependent and independent antibody production is effected by intravenous immunoglobulin. It is increasingly clear that in ITP at least the clinical response to IV IgG is a summation of several cellular events and their balance reflects the ultimate outcome. It may eventually be possible to use these observations to predict the likely outcome in the individual patient of this mode of therapy.
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newland1970blutcellular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors A. C. Newland;M. G. Macey;P. A. Veys;A. C. Newland;M. G. Macey;P. A. Veys;
Journal blut
Year 1970
DOI
doi:10.1007/BF00320254
URL
https://link.springer.com/article/10.1007/BF00320254
Keywords
oncology hematology

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