two distinct pathways to development of squamous cell carcinoma of the vulva

Clicks: 129
ID: 259672
2011
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Abstract
Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional increase in the average age of the general population. Two different pathways for vulvar SCC have been put forth. The first pathway is triggered by infection with a high-risk-type Human Papillomavirus (HPV). Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with overexpression of p14ARF and p16INK4A. This lesion subsequently forms a warty- or basaloid-type SCC. The HPV vaccine is a promising new tool for prevention of this HPV related SCC of the vulva. The second pathway is HPV-independent. Keratinizing SCC develops within a background of lichen sclerosus (LS) through a differentiated VIN. It has a different set of genetic alterations than those in the first pathway, including p53 mutations, allelic imbalances (AI), and microsatellite instability (MSI). Further clinical and basic research is still required to understand and prevent vulvar SCC. Capsule. Two pathway for pathogenesis of squamous cell carcinoma of the value are reviewed.
Reference Key
ueda2011journaltwo Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yutaka Ueda;Takayuki Enomoto;Toshihiro Kimura;Kiyoshi Yoshino;Masami Fujita;Tadashi Kimura
Journal case reports in hematology
Year 2011
DOI
10.1155/2011/951250
URL
http://dx.doi.org/10.1155/2011/951250
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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