development and application of spectrophotometric method for the determination of cefaclor in pharmaceutical formulations

Clicks: 225
ID: 259553
2009
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Abstract
A simple, fast and sensitive spectrophotometric method for the determination of cefaclor in pharmaceutical raw and dosage forms based on reaction with ninhydrin is developed, optimized and validated. The purple color (Ruhemenn's purple) that resulted from the reaction was stabilized and measured at 560 nm. Beer's law is obeyed in the concentration range of 4-80 µg mL-1 with molar absorptivity of 1.42 × 10(5) L mole-1 cm-1. All variables including the reagent concentration, heating time, reaction temperature, color stability period, and cefaclor/ninhydrin ratio were studied in order to optimize the reaction conditions. No interference was observed from common pharmaceutical adjuvant. The developed method is easy to use, accurate and highly cost-effective for routine studies relative to HPLC and other techniques.
Reference Key
raza2009qumicadevelopment Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Asad Raza;Abdul Subhan Ijaz;Shabbir Ahmad
Journal greece and rome
Year 2009
DOI
10.1590/S0100-40422009000500018
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500018
Keywords
cefaclor

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