development of one-pot three component reaction for the synthesis of n′-aryl-n-cyanoformamidines, essential precursors of formamidine pesticides family
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ID: 259364
2016
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Abstract
Efficient one-pot three component reaction of aniline derivatives with cyanoamide and triethyl orthoformate at reflux in toluene affords N′-aryl-N-cyanoformamidines in high yields just by the distillation of the azeotrope toluene/ethyl alcohol. Labelled d9-Amitraz is prepared by the application of this procedure in the synthesis of formamidine pesticides family.
| Reference Key |
nino2016arabiandevelopment
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|---|---|
| Authors | ;Antonio De Nino;Loredana Maiuolo;Monica Nardi;Raffaele Pasceri;Antonio Procopio;Beatrice Russo |
| Journal | Behavioural brain research |
| Year | 2016 |
| DOI |
10.1016/j.arabjc.2015.06.016
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| URL | |
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