induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain

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ID: 259227
2014
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Abstract
Differentiated cells can be converted directly into multipotent neural stem cells (i.e., induced neural stem cells [iNSCs]). iNSCs offer an attractive alternative to induced pluripotent stem cell (iPSC) technology with regard to regenerative therapies. Here, we show an in vivo long-term analysis of transplanted iNSCs in the adult mouse brain. iNSCs showed sound in vivo long-term survival rates without graft overgrowths. The cells displayed a neural multilineage potential with a clear bias toward astrocytes and a permanent downregulation of progenitor and cell-cycle markers, indicating that iNSCs are not predisposed to tumor formation. Furthermore, the formation of synaptic connections as well as neuronal and glial electrophysiological properties demonstrated that differentiated iNSCs migrated, functionally integrated, and interacted with the existing neuronal circuitry. We conclude that iNSC long-term transplantation is a safe procedure; moreover, it might represent an interesting tool for future personalized regenerative applications.
Reference Key
hemmer2014steminduced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kathrin Hemmer;Mingyue Zhang;Thea van Wüllen;Marna Sakalem;Natalia Tapia;Aidos Baumuratov;Christian Kaltschmidt;Barbara Kaltschmidt;Hans R. Schöler;Weiqi Zhang;Jens C. Schwamborn
Journal nature reviews gastroenterology & hepatology
Year 2014
DOI
10.1016/j.stemcr.2014.06.017
URL
http://www.sciencedirect.com/science/article/pii/S2213671114002033
Keywords
medicine (general)biology (general)

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