long-term recording of ltp in cultured hippocampal slices
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ID: 259204
2002
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Abstract
Long-term potentiation (LTP) was elicited
by high frequency stimulation in hippocampal
slices cultured on multi-electrode arrays. LTP
lasting more than 1 h was recorded in 75% of
slices, and a significant number of slices
exhibited a non-decaying LTP that lasted more
than 48 h. LTP induction was completely and
reversibly blocked by an antagonist of the
NMDA receptor, APV. Our results suggest the
possibility of using chronic recording in
hippocampal slices cultured on multi-electrode
arrays to study the mechanisms underlying
LTP maintenance and stabilization.
| Reference Key |
shimono2002neurallong-term
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|---|---|
| Authors | ;Ken Shimono;Michel Baudry;Lam Ho;Makoto Taketani;Gary Lynch |
| Journal | tetrahedron |
| Year | 2002 |
| DOI |
10.1155/NP.2002.249
|
| URL | |
| Keywords |
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