how do cells make decisions: engineering micro- and nanoenvironments for cell migration

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ID: 259175
2010
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Abstract
Cell migration contributes to cancer metastasis and involves cell adhesion to the extracellular matrix (ECM), force generation through the cell's cytoskeletal, and finally cell detachment. Both adhesive cues from the ECM and soluble cues from neighbouring cells and tissue trigger intracellular signalling pathways that are essential for cell migration. While the machinery of many signalling pathways is relatively well understood, how hierarchies of different and conflicting signals are established is a new area of cellular cancer research. We examine the recent advances in microfabrication, microfluidics, and nanotechnology that can be utilized to engineer micro- and nanoscaled cellular environments. Controlling both adhesive and soluble cues for migration may allow us to decipher how cells become motile, choose the direction for migration, and how oncogenic transformations influences these decision-making processes.
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ngalim2010journalhow Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Siti Hawa Ngalim;Astrid Magenau;Guillaume Le Saux;J. Justin Gooding;Katharina Gaus
Journal joule
Year 2010
DOI
10.1155/2010/363106
URL
http://dx.doi.org/10.1155/2010/363106
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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