what we are learning on htlv-1 pathogenesisfrom animal models
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2012
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Abstract
Isolated and identified more than 30 years ago, Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL), an aggressive lymphoproliferative disease of activated CD4+ T cells, and other inflammatory disorders such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A variety of animal models have contributed to the fundamental knowledge of HTLV-1 transmission, pathogenesis and to the design of novel therapies to treat HTLV-1 associated diseases. Small animal models (rabbits, rats, mice) as well as large animal models (monkeys) have been utilized to significantly advance characterization of the viral proteins and of virus-infected cells in the early steps of infection, as well as in the development of leukemogenic and immunopathogenic processes. Over the past two decades, the creation of new immuno-compromised mouse strains that are robustly reconstituted with a functional human immune system (HIS) after being transplanted with human tissues or progenitor cells has revolutionized the in vivo investigation of viral infection and pathogenesis. Recent observations obtained in HTLV-1-infected humanized HIS mice that develop lymphomas provide the opportunity to study the evolution of the proviral clonality in human T cells present in different lymphoid organs. Current progress in the improvement of those humanized models will favor the testing of drugs and the development of targeted therapies against HTLV-1-associated diseases.
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dodon2012frontierswhat
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| Authors | ;Madeleine eDuc Dodon;Julien eVillaudy;Louis eGazzolo;Robyn eHaines;Michael eLairmore |
| Journal | journal of magnetic resonance (san diego, calif : 1997) |
| Year | 2012 |
| DOI |
10.3389/fmicb.2012.00320
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