study of specific ige and igg4 antibodies to mite antigen in asthmatic children during immunotherapy
Clicks: 227
ID: 257736
1998
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
30.0
/100
227 views
30 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #69 of 108 articles by views in current drug discovery technologies
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Using immunoblotting and densitometer techniques, we followed the levels of IgE and IgG4 antibodies to Dermatophagoides farinae antigen in the sera of 12 asthmatic children during immunotherapy, repeated injections of house dust extract, for 2 years. The symptoms of asthma were reduced or disappeared by the 6th month after starting immunotherapy in 12 children. Two years later, RAST scores to house dust and D. farinae in each child were still 4 or 5. The levels of IgE antibodies to Der fII in all cases did not change drastically. IgE antibodies to higher molecular weight antigens (Der fI, fIII, fIV etc.) developed in some cases, suggesting that repeated injections of crude extract tended to induce IgE antibodies to alternative molecules in patients. The IgG4 antibody to Der fII increased in 10 cases, while that to Der fI increased in three of 12 cases, indicating that production of IgG4 antibodies to mite antigens started and expanded with repeated injections of house dust extract. The amount of induced IgG4 antibodies to Der fI and Der fII was not enough to inhibit the immunoblot reaction of IgE antibodies to these molecules.
| Reference Key |
matsuoka1998allergologystudy
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Hiroyuki Matsuoka;Yutaka Atsuta;Hisashi Matsubara;Motoi Adachi;Yukari Matsushita;Toshihide Obe;Katsuhiko Ando;Yasuo Chinzei |
| Journal | current drug discovery technologies |
| Year | 1998 |
| DOI |
10.2332/allergolint.47.123
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.