endocannabinoids, related compounds and their metabolic routes
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ID: 257504
2014
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Abstract
Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.
| Reference Key |
fezza2014moleculesendocannabinoids,
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|---|---|
| Authors | ;Filomena Fezza;Monica Bari;Rita Florio;Emanuela Talamonti;Monica Feole;Mauro Maccarrone |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules191117078
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| URL | |
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