Microbial Regulation in Gorgonian Corals

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ID: 25730
2012
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Abstract
Gorgonian corals possess many novel natural products that could potentially mediate coral-bacterial interactions. Since many bacteria use quorum sensing (QS) signals to facilitate colonization of host organisms, regulation of prokaryotic cell-to-cell communication may represent an important bacterial control mechanism. In the present study, we examined extracts of twelve species of Caribbean gorgonian corals, for mechanisms that regulate microbial colonization, such as antibacterial activity and QS regulatory activity. Ethanol extracts of gorgonians collected from Puerto Rico and the Florida Keys showed a range of both antibacterial and QS activities using a specific <em>Pseudomonas aeruginosa</em> QS reporter,<em> </em>sensitive to long chain AHLs and a short chain <em>N</em>-acylhomoserine lactones (AHL) biosensor, <em>Chromobacterium violaceium</em>. Overall, the gorgonian corals had higher antimicrobial activity against non-marine strains when compared to marine strains. <em>Pseudopterogorgia americana</em>, <em>Pseusopterogorgia acerosa</em>, and <em>Pseudoplexuara flexuosa</em> had the highest QS inhibitory effect. Interestingly, <em>Pseudoplexuara porosa</em> extracts stimulated QS activity with a striking 17-fold increase in signal. The stimulation of QS by <em>P. porosa</em> or other elements of the holobiont may encourage colonization or recruitment of specific microbial species. Overall, these results suggest the presence of novel stimulatory QS, inhibitory QS and bactericidal compounds in gorgonian corals. A better understanding of these compounds may reveal insight into coral-microbial ecology and whether a therapeutic potential exists.
Reference Key
mydlarz2012microbialmarine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mydlarz, Laura D.;Hunt, Laura R.;Smith, Stephanie M.;Downum, Kelsey R.;
Journal Marine drugs
Year 2012
DOI
DOI not found
URL
http://www.mdpi.com/1660-3397/10/6/1225
Keywords Keywords not found

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