hypocalcemia and tetany caused by vitamin d deficiency in a child with intestinal lymphangiectasia
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ID: 257131
2009
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Abstract
Primary intestinal lymphangiectasia is a rare disease of children, which is characterized by chronic diarrhea and complicated with malnutrition, including fat-soluble vitamin deficiency. We report a girl aged 4 years and 8 months who was diagnosed with the disease by endoscopic duodenal biopsy at 8 months of age. She presented initially with chronic diarrhea at 4 months of age. Generalized edema with hypoalbuminemia frequently occurred despite regular albumin supplements. Multiple vitamins initially were not supplied regularly. Episodes of tetany caused by hypocalcemia developed 4 years after the diagnosis of intestinal lymphangiectasia. Imaging study (long-bone X-ray and dual-energy X-ray absorptiometry) revealed low bone density. Complicated vitamin D deficiency [low serum 25-hydroxy vitamin D concentration (< 12.48 mmol/L, the detection limit)] and secondary hyperparathyroidism were confirmed via blood testing. Vitamin D supplementation for 3 months improved her bone density, secondary hyperparathyroidism and frequent tetany. Vitamin D status should be monitored in patients with intestinal lymphangiectasia.
| Reference Key |
lu2009journalhypocalcemia
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|---|---|
| Authors | ;Ying-Yi Lu;Jia-Feng Wu;Yen-Hsuan Ni;Steven Shinn-Forng Peng;Shun Chia-Tung;Mei-Hwei Chang |
| Journal | Bioorganic & medicinal chemistry letters |
| Year | 2009 |
| DOI |
10.1016/S0929-6646(09)60410-1
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