a retrospective on nuclear receptor regulation of inflammation: lessons from gr and ppars

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ID: 256898
2011
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Abstract
Members of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF-κB signaling pathways. Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of inflammation. This review examines the history and current advances in nuclear receptor regulation of inflammation by the crosstalk with AP-1 and NF-κB signaling, focusing on the roles of GR and PPARs. A better understanding of the molecular mechanism by which nuclear receptors inhibit proinflammatory signaling pathways will enable novel therapies to treat chronic inflammation.
Reference Key
li2011ppara Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Min-Dian Li;Xiaoyong Yang
Journal Life (Basel, Switzerland)
Year 2011
DOI
10.1155/2011/742785
URL
http://dx.doi.org/10.1155/2011/742785
Keywords
Biology (General)

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