site-specific methylation changes in the glucocorticoid receptor exon 1f promoter in relation to life adversity: systematic review of contributing factors
Clicks: 245
ID: 255631
2014
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Emerging Content
30.0
/100
244 views
24 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
There has been recent interest in epigenetics in psychiatry since it offers a means of understanding how stressful life experiences, in interaction with the genotype, result in epigenetic changes that result in altered gene expression, ultimately affecting the risk for mental disorders. Many studies focused on methylation of the glucocorticoid receptor exon 1F promoter following an initial observation that changes in this region could be modulated by the environment. This review examines all published studies that have attempted to measure methylation in this region using different techniques, several tissue types, populations at different behavioral state and stages of development. Methodological issues have been raised with the aim of attempting to understand methylation quantification and site of action. We propose that it is useful to examine whether methylation at specific sites within the promoter region may be particularly relevant to psychiatric vulnerability to stress-related outcomes.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (144 words).
Try re-searching for a better abstract.
| Reference Key |
daskalakis2014frontierssite-specific
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Nikolaos P Daskalakis;Nikolaos P Daskalakis;Rachel eYehuda;Rachel eYehuda |
| Journal | Journal of enzyme inhibition and medicinal chemistry |
| Year | 2014 |
| DOI |
10.3389/fnins.2014.00369
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.