the central mechanisms of secretin in regulating multiple behaviors

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ID: 255211
2014
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Abstract
Secretin (SCT) was firstly discovered as a gut peptide hormone in stimulating pancreatic secretion, while its novel neuropeptide role has drawn substantial research interests in recent years. SCT and its receptor (SCTR) are widely expressed in different brain regions, where they exert multiple cellular functions including neurotransmission, gene expression regulation, neurogenesis and neural protection. As all these neural functions ultimately can affect behaviors, it is hypothesized that SCT controls multiple behavioral paradigms. Current findings support this hypothesis as SCT-SCTR axis participates in modulating social interaction, spatial learning, water and food intake, motor coordination and motor learning behaviors. This mini-review focuses on various aspects of SCT and SCTR in hippocampus, hypothalamus and cerebellum including distribution profiles, cellular functions and behavioral phenotypes to elucidate the link between cellular mechanisms and behavioral control.
Reference Key
ezhang2014frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Li eZhang;Billy K C Chow
Journal aip advances
Year 2014
DOI
10.3389/fendo.2014.00077
URL
http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00077/full
Keywords
fear alzheimer’s disease event-related potential γ-secretase time perception clinical endocrinology neuropsychiatry biological psychiatry

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