high-sensitivity troponin t: a biomarker for diuretic response in decompensated heart failure patients

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ID: 255196
2014
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Abstract
Background. Patients presenting with acutely decompensated heart failure (ADHF) and positive circulating cardiac troponins were found to be a high-risk cohort. The advent of high-sensitive troponins resulted in a detection of positive troponins in a great proportion of heart failure patients. However, the pathophysiological significance of this phenomenon is not completely clear. Objectives. The aim of this study is to determine the early evolution and clinical significance of high-sensitivity troponin T (hsTnT) in ADHF. Methods. Retrospective, secondary analysis of a prospective study including 100 patients with ADHF. Results. Globally, high-sensitivity troponin T decreased from day 1 to day 3 (P=0,039). However, in the subgroup of patients who remained decompensated no significant differences in hsTnT from day 1 to day 3 were observed (P=0,955), whereas in successfully compensated patients a significant reduction in hsTnT levels was observed (P=0,025). High-sensitivity troponin T decrease was correlated with NTproBNP reduction (P=0,007). Patients with hsTnT increase had longer length of stay (P=0,033). Conclusions. Episodes of ADHF are associated with transient increases in the blood levels of hsTnT that are reduced with effective acute episode treatment. The decrease in hsTnT can translate less myocardial damage along with favourable ADHF treatment.
Reference Key
ferreira2014cardiologyhigh-sensitivity Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;João Pedro Ferreira;Mário Santos;Sofia Almeida;Irene Marques;Paulo Bettencourt;Henrique Carvalho
Journal acta crystallographica section c, structural chemistry
Year 2014
DOI
10.1155/2014/269604
URL
http://dx.doi.org/10.1155/2014/269604
Keywords
Diseases of the circulatory (Cardiovascular) system

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