when insult is added to injury: cross talk between ilcs and intestinal epithelium in ibd

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ID: 254575
2016
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Abstract
Inflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine. The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lamina propria. In addition to its crucial role in protecting the body from invading pathogens, the intestinal epithelium contributes to intestinal homeostasis by its biochemical properties and communication to underlying immune cells. Innate lymphoid cells (ILCs) are a recently described population of lymphocytes that have been implicated in both mucosal homeostasis and inflammation. Recent findings indicate a critical feedback loop in which damaged epithelium activates these innate immune cells to restore epithelial barrier function. This review will focus on the signalling pathways between damaged epithelium and ILCs involved in repair of the epithelial barrier and tissue homeostasis and the relationship of these processes with the control of IBD.
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gracht2016mediatorswhen Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Esmé van der Gracht;Sonja Zahner;Mitchell Kronenberg
Journal polyhedron
Year 2016
DOI
10.1155/2016/9765238
URL
http://dx.doi.org/10.1155/2016/9765238
Keywords
pathology

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