altered p16ink4 and rb1 expressions are associated with poor prognosis in patients with nonsmall cell lung cancer

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ID: 253992
2012
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Abstract
p16INK4 and RB1 are two potent cell cycle regulators to control the G1/S transition by interacting with CDK4/6, E2F, and D-type cyclins, respectively. Depending on the tumour type, genetic alterations resulting in the functional inactivation have frequently been reported in both genes. By contrast, much less is known regarding the overexpression of these proteins in the tumor cells. In this study, expressions of p16INK4 RB1, and CDKN2A copy number variances (CNV) in the tumor cells were assessed by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, in 73 nonsmall cell lung cancer (NSCLC) with known 5-year survivals. The histologic type (P=0.01), p16INK4 (P=0.004), and RB1 (P<0.001) were predictive of survivals. The CDKN2A CNV (P<0.05) was also significant when compared to those cases without CNV. Therefore, among the molecular genetic prognostic factors, expressions of RB1 and p16INK4 in the tumor cells were the most strongly predictive of adverse outcomes in stage I and II nonsquamous NSCLC.
Reference Key
zhao2012journalaltered Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Weiqiang Zhao, Cheng C. Huang, Gregory A. Otterson, Marino E. Leon, Yan Tang, Konstantin Shilo, Miguel A. Villalona
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Journal joule
Year 2012
DOI
10.1155/2012/957437
URL
http://dx.doi.org/10.1155/2012/957437
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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