tratamento de vasculopatia livedóide com imunoglobulina intravenosa treatment of livedoid vasculopathy with intravenous immunoglobulin

Clicks: 307
ID: 253956
2008
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Abstract
A vasculopatia livedóide apresenta-se com dor e úlceras de cicatrização lenta em membros inferiores, e fisiopatologia obscura. As estratégias terapêuticas incluem cicatrizantes, antiinflamatórios e imunossupressores, sem relatos de benefício permanente. Administrou-se imunoglobulina em paciente refratário a outras terapias e avaliou-se o comprometimento da pele antes e depois por meio de escore clínico. Houve regressão significativa das lesões. A droga foi bem tolerada, e a terapia foi finalizada.
Livedoid vasculopathy presents with pain and slowly healing ulcerations of the lower limbs, and has obscure pathophysiology. Usual therapeutics include rheologic, anti-inflammatory and immunosuppressing agents with no reports of permanent benefits. Immunoglobulin was administered to a patient who was refractory to other treatments and skin involvement was assessed by means of clinical score before and after treatment. There was a significant healing of the lesions. Imunoglobulim was well tolerated and therapy was discontinued.
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Authors ;Jader Freire Sobral Filho;Milane Caroline de Oliveira Valdek;Luiza Toscano Dias Rodrigues
Journal Theriogenology
Year 2008
DOI
10.1590/S0365-05962008000400014
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962008000400014
Keywords
skin diseases immunoglobulin intravenous treatment outcomedermatology

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