estimation of loxoprofen sodium dihydrate in tablets by reverse phase high performance liquid chromatography
Clicks: 258
ID: 253939
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.3
/100
258 views
58 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #86 of 167 articles by views in Behavioural brain research
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 167 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
A simple and rapid reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the estimation of loxoprofen sodium dihydrate (LSD) in tablets. An isocratic HPLC analysis was performed on Phenomenex, Luna C18(2) (250 × 4.6 mm, 5μ) column. The compound was separated with the mixture of 0.4% orthophosphoric acid and acetonitrile in the ratio of 45:55 (v/v) as a mobile phase at a flow rate of 1.0 mL/min. UV detection was performed at 210 nm. Run time per sample was 8 min with the retention time of 4.9 min. The system suitability parameters, such as theoretical plate count, tailing and% RSD between six standard injections were within the limits. The method was validated according to ICH guidelines. The method was validated for specificity, precision, linearity, stability of sample solution, intermediate precision, robustness and accuracy. The stability of the sample solution was checked for 24 h at one hour intervals. The results show that the sample solution is stable for at least 24 h. Calibration plots were linear over the concentration range of 10–90 μg/mL as indicated by the correlation coefficient of 0.9992. The% RSD was 0.115 and 1.288 for system precision and method precision, respectively. The % RSD values for intermediate precision studies were less than 2%. The robustness of the method was evaluated by deliberately altering the chromatographic conditions and the results were adhered with the limits. The high recovery and low relative standard deviation confirm the suitability of the method for the estimation of loxoprofen sodium dihydrate in tablets.
| Reference Key |
nanthakumar2016arabianestimation
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;R. Nanthakumar;V. Prabakaran;K. Chitra;C. Uma Maheswara Reddy |
| Journal | Behavioural brain research |
| Year | 2016 |
| DOI |
10.1016/j.arabjc.2011.07.010
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.