bioactive diphenyl ethers and isocoumarin derivatives from a gorgonian-derived fungus phoma sp. (ta07-1)
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ID: 253791
2017
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Abstract
Three new diphenyl ether derivatives—phomaethers A–C (1–3) and five known compounds—including a diphenyl ether analog, 2,3′-dihydroxy-4-methoxy-5′,6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)—were isolated from a gorgonian-derived fungus Phoma sp. (TA07-1). Their structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by acid hydrolysis reactions. It was the first report to discover the diphenyl glycoside derivatives from coral-derived fungi. Compounds 1, 3, and 4 showed selective strong antibacterial activity against five pathogenic bacteria with the minimum inhibiting concentration (MIC) values and minimum bactericidal concentration (MBC) values between 0.156 and 10.0 μM.
| Reference Key |
shi2017marinebioactive
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|---|---|
| Authors | ;Ting Shi;Jun Qi;Chang-Lun Shao;Dong-Lin Zhao;Xue-Mei Hou;Chang-Yun Wang |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2017 |
| DOI |
10.3390/md15060146
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