epicardium formation as a sensor in toxicology

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ID: 253775
2013
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Abstract
Zebrafish (Danio rerio) are an excellent vertebrate model for studying heart development, regeneration and cardiotoxicity. Zebrafish embryos exposed during the temporal window of epicardium development to the aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exhibit severe heart malformations. TCDD exposure prevents both proepicardial organ (PE) and epicardium development. Exposure later in development, after the epicardium has formed, does not produce cardiac toxicity. It is not until the adult zebrafish heart is stimulated to regenerate does TCDD again cause detrimental effects. TCDD exposure prior to ventricular resection prevents cardiac regeneration. It is likely that TCDD-induced inhibition of epicardium development and cardiac regeneration occur via a common mechanism. Here, we describe experiments that focus on the epicardium as a target and sensor of zebrafish heart toxicity.
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heideman2013journalepicardium Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Warren Heideman;Jessica Plavicki;Peter Hofsteen;Richard E. Peterson
Journal journal of counseling psychology
Year 2013
DOI
10.3390/jdb1020112
URL
http://www.mdpi.com/2221-3759/1/2/112
Keywords
ahr tcdd heart regenerationbiology (general)

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