functional studies of micrornas in neural stem cells: problems and perspectives.

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ID: 253771
2012
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Abstract
In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone at the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9 and let-7. We also highlight technical strategies used to investigate miRNA function, accentuating limitations and potentials.
Reference Key
ekerblom2012frontiersfunctional Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Malin eÅkerblom;Rohit eSachdeva;Johan eJakobsson
Journal Journal of enzyme inhibition and medicinal chemistry
Year 2012
DOI
10.3389/fnins.2012.00014
URL
http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00014/full
Keywords
microrna neurogenesis neural stem cells let-7 neuropsychiatry biological psychiatry mir-124neurosciences

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