functional studies of micrornas in neural stem cells: problems and perspectives.
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2012
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Abstract
In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone at the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9 and let-7. We also highlight technical strategies used to investigate miRNA function, accentuating limitations and potentials.
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ekerblom2012frontiersfunctional
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| Authors | ;Malin eÅkerblom;Rohit eSachdeva;Johan eJakobsson |
| Journal | Journal of enzyme inhibition and medicinal chemistry |
| Year | 2012 |
| DOI |
10.3389/fnins.2012.00014
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