cellular structural changes in candida albicans caused by the hydroalcoholic extract from sapindus saponaria l.

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ID: 253009
2015
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Abstract
Vulvovaginal candidiasis (VVC) is a disease caused by the abnormal growth of yeast-like fungi in the mucosa of the female genital tract. Candida albicans is the principal etiological agent involved in VVC, but reports have shown an increase in the prevalence of Candida non-C. albicans (CNCA) cases, which complicates VVC treatment because CNCA does not respond well to antifungal therapy. Our group has reported the in vitro antifungal activity of extracts from Sapindus saponaria L. The present study used scanning electron microscopy and transmission electron microscopy to further evaluate the antifungal activity of hydroalcoholic extract from S. saponaria (HE) against yeast obtained from VVC and structural changes induced by HE. We observed the antifungal activity of HE against 125 vaginal yeasts that belonged to four different species of the Candida genus and S. cerevisae. The results suggest that saponins that are present in HE act on the cell wall or membrane of yeast at the first moments after contact, causing damage to these structures and cell lysis.
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shinobu-mesquita2015moleculescellular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Cristiane S. Shinobu-Mesquita;Patricia S. Bonfim-Mendonça;Amanda L. Moreira;Izabel C. P. Ferreira;Lucelia Donatti;Adriana Fiorini;Terezinha I. E. Svidzinski
Journal Journal of ethnopharmacology
Year 2015
DOI
10.3390/molecules20059405
URL
http://www.mdpi.com/1420-3049/20/5/9405
Keywords
antifungals

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