myositis, ganglioneuritis, and myocarditis with distinct perifascicular muscle atrophy in a 2-year-old male boxer

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ID: 252896
2018
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Abstract
A 2-year-old male, intact Boxer was referred for chronic diarrhea, hyporexia, labored breathing, weakness and elevated creatine kinase, and alanine aminotransferase activities. Initial examination and diagnostics revealed a peripheral nervous system neurolocalization, atrial premature complexes, and generalized megaesophagus. Progressive worsening of the dog’s condition was noted after 36 h; the dog developed aspiration pneumonia, was febrile and oxygen dependent. The owners elected humane euthanasia. Immediately postmortem biopsies of the left cranial tibial and triceps muscles and the left peroneal nerve were obtained. Postmortem histology revealed concurrent myositis, myocarditis, endocarditis, and ganglioneuritis. Mixed mononuclear cell infiltrations and a distinct perifascicular pattern of muscle fiber atrophy was present in both muscles. This is a novel case of diffuse inflammatory myopathy with a distinct perifascicular pattern of atrophy in addition to endocarditis, myocarditis, and epicarditis.
Reference Key
rossman2018frontiersmyositis, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Paul M. Rossman;Stephanie A. Thomovsky;Ryan M. Schafbuch;Ling T. Guo;G. D. Shelton
Journal Current microbiology
Year 2018
DOI
10.3389/fvets.2018.00020
URL
http://journal.frontiersin.org/article/10.3389/fvets.2018.00020/full
Keywords
myositis myocarditis endocarditis

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