clinical assessment and health-related quality of life in patients with non-cardiac chest pain

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ID: 252872
2015
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Abstract
Introduction: Non-cardiac chest pain (NCCP) is mainly related to oesophageal disease, and in spite of being a common condition in Mexico, information regarding it is scarce. Aim: To assess the clinical characteristics and health-related quality of life of patients with NCCP of presumed oesophageal origin. Material and methods: Patients with NCCP of presumed oesophageal origin with no previous treatment were included in the study. Associated symptoms were assessed and upper gastrointestinal endoscopy and 24-hour oesophageal pH monitoring were performed to diagnose gastroesophageal reflux disease, while oesophageal manometry was used to determine oesophageal motility disorders. The SF-36 Health-Related Quality of Life (HR-QoL) questionnaire was completed and its results compared to a control group without oesophageal symptoms. Results: The study included 33 patients, of which 61% were women, and the mean age was 46.1 (± 11.6) years. Causes of NCCP were gastroesophageal reflux disease in 48%, achalasia in 34%, and functional chest pain in 18%. The average progression time for chest pain was 24 (2-240) months, with ≤3 events/week in 52% of the patients. The most frequent accompanying symptoms were: regurgitation (81%), dysphagia (72%) and heartburn (66%). Patients with NCCP show deterioration in HR-QoL compared to the control group (P = .01), regardless of chest pain aetiology. The most affected areas were general perception of health, emotional issues, and mental health sub-scale (P > 0.05). Conclusions: In our population, patients with NCCP show deterioration in HR-QoL regardless of the aetiology, frequency, and accompanying symptoms.
引言：非心源性胸痛（NCCP）主要与食管疾病相关，尽管该病在墨西哥较为常见，但相关临床资料依然匮乏。 目的：评估疑似食管源性NCCP患者的临床特征及其健康相关生活质量（HR-QoL）。 材料与方法：本研究纳入了既往未经治疗的疑似食管源性NCCP患者。评估其伴随症状，通过上消化道内镜检查和24小时食管pH监测诊断胃食管反流病，并采用食管测压法评估食管动力障碍。患者完成SF-36健康相关生活质量问卷调查，并将其结果与无食管症状的对照组进行比较。 结果：研究共纳入33例患者，其中女性占61%，平均年龄为46.1（± 11.6）岁。NCCP的病因分别为胃食管反流病（48%）、贲门失弛缓症（34%）和功能性胸痛（18%）。胸痛平均病程为24（2-240）个月，52%的患者发作频率≤3次/周。最常见的伴随症状为反流（81%）、吞咽困难（72%）和烧心（66%）。与对照组相比，无论胸痛病因如何，NCCP患者的HR-QoL均出现下降（P = .01）。受影响最严重的维度为总体健康感知、情感问题和心理健康亚量表（P > 0.05）。 结论：在受试人群中，无论病因、发作频率及伴随症状如何，NCCP患者的HR-QoL均显著受损。
Reference Key
ortiz-garrido2015revistaclinical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;O. Ortiz-Garrido;N.X. Ortiz-Olvera;M. González-Martínez;S. Morán-Villota;G. Vargas-López;M. Dehesa-Violante;A. Ruiz-de León
Journal Molecular brain
Year 2015
DOI
10.1016/j.rgmxen.2015.07.003
URL
http://www.sciencedirect.com/science/article/pii/S2255534X15000493
Keywords
gastroesophageal reflux disease achalasia Gastroenterology

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