application of sialic acid/polysialic acid in the drug delivery systems
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ID: 252783
2014
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Abstract
The properties of modified biomaterial are gaining more and more importance in drug delivery systems. Sialic acid (SA) and polysialic acid (PSA) serve as endogenous substances, which are non-immunogenic and biodegradable. At the same time, SA modification of the drugs/carriers can enhance the uptake of tumor cell and retention in brain; PSA modification can reduce the immunogenicity of the proteins or polypeptides and increase circulation time of the modified drugs/carriers in the blood, thus achieving active targeting effect. These properties offer a variety of opportunities for applications in drug delivery systems. This article summarizes the biological functions of SA and PSA and presents the technologies of SA/PSA modified small molecule drugs, proteins and carriers in drug delivery systems.
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zhang2014asianapplication
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| Authors | ;Ting Zhang;Zhennan She;Zhenjun Huang;Jing Li;Xiang Luo;Yihui Deng |
| Journal | topics in organometallic chemistry |
| Year | 2014 |
| DOI |
10.1016/j.ajps.2014.03.001
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