application of sialic acid/polysialic acid in the drug delivery systems

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ID: 252783
2014
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Abstract
The properties of modified biomaterial are gaining more and more importance in drug delivery systems. Sialic acid (SA) and polysialic acid (PSA) serve as endogenous substances, which are non-immunogenic and biodegradable. At the same time, SA modification of the drugs/carriers can enhance the uptake of tumor cell and retention in brain; PSA modification can reduce the immunogenicity of the proteins or polypeptides and increase circulation time of the modified drugs/carriers in the blood, thus achieving active targeting effect. These properties offer a variety of opportunities for applications in drug delivery systems. This article summarizes the biological functions of SA and PSA and presents the technologies of SA/PSA modified small molecule drugs, proteins and carriers in drug delivery systems.
Reference Key
zhang2014asianapplication Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ting Zhang;Zhennan She;Zhenjun Huang;Jing Li;Xiang Luo;Yihui Deng
Journal topics in organometallic chemistry
Year 2014
DOI
10.1016/j.ajps.2014.03.001
URL
http://www.sciencedirect.com/science/article/pii/S1818087614000105
Keywords
sialic acid active targeting drug delivery system pharmacology circulation timetherapeutics

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