marine bromophenol derivative 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol protects hepatocytes from lipid-induced cell damage and insulin resistance via ptp1b inhibition
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2015
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Abstract
3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol (HPN) is a bromophenol derivative from the marine red alga Rhodomela confervoides. We have previously found that HPN exerted an anti-hyperglycemic property in db/db mouse model. In the present study, we found that HPN could protect HepG2 cells against palmitate (PA)-induced cell death. Data also showed that HPN inhibited cell death mainly by blocking the cell apoptosis. Further studies demonstrated that HPN (especially at 1.0 μM) significantly restored insulin-stimulated tyrosine phosphorylation of IR and IRS1/2, and inhibited the PTP1B expression level in HepG2 cells. Furthermore, the expression of Akt was activated by HPN, and glucose uptake was significantly increased in PA-treated HepG2 cells. Our results suggest that HPN could protect hepatocytes from lipid-induced cell damage and insulin resistance via PTP1B inhibition. Thus, HPN can be considered to have potential for the development of anti-diabetic agent that could protect both hepatic cell mass and function.
| Reference Key |
luo2015marinemarine
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| Authors | ;Jiao Luo;Ning Wu;Bo Jiang;Lijun Wang;Shuaiyu Wang;Xiangqian Li;Baocheng Wang;Changhui Wang;Dayong Shi |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2015 |
| DOI |
10.3390/md13074452
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| URL | |
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