development and evaluation of a hydrophilic matrix as a buccoadhesive system containing diclofenac sodium

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ID: 252217
2011
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Abstract
The aim of this work was to study the development and evaluation of a hydrolphilic matrix as a buccoadhesive system containing diclofenac sodium. Eleven formulations were prepared containing the following bioadhesive polymers: hydroxylpropylmethylcellulose, polycarbophil, guar gum and xanthan gum individually and in combination. All the formulations were evaluated for the swelling index, adhesive index, and the time of adhesive and drug release profile (%). The results showed that the formulations that presented the most swelling index were the F3 (PAA/GX) and F6 (GG/GX). The smaller index swelling was for F1 (PAA/CM) and F10 (HPCMC/CM). The F4 (PAA/HPMC) formulation presented the best adhesive index and F10 (HPMC/CM) the worst. F1 (PAA/CM) was the best matrix hydrophilic adhesive for controlled release. The hydroxylpropylmethylcellulose, guar and xanthan gum when used individually presented low adhesiveness.
Reference Key
wypych2011braziliandevelopment Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Thaiz Cristina Wypych;Itamar Francisco Andreazza
Journal current drug delivery
Year 2011
DOI
10.1590/S1516-89132011000500006
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500006
Keywords
guar gum diclofenac sodium polycarbophilbiotechnology

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