cathodic adsorptive stripping voltammetry of an anti-emetic agent granisetron in pharmaceutical formulation and biological matrix

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ID: 251982
2012
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Abstract
Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode (HMDE) in the potential range from −1.3 to −1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45% at square-wave voltammetry and 5.33% at cyclic voltammetry as compared with the non stripping techniques. The proposed voltammetric method allowed quantification of Granisetron in pharmaceutical formulation over the target concentration range of 50–200 ng/mL with detection limit 13.63 ng/mL, whereas in human plasma 50–225 ng/mL with detection limit 11.75 ng/mL. Keywords: Granisetron, Human plasma, Solid-phase extraction, Pharmaceutical formulation, Voltammetry, Hanging mercury drop electrode
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jain2012journalcathodic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rajeev Jain, Ramkishor Sharma
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Journal Frontiers in plant science
Year 2012
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S2095177912000457
Keywords
therapeutics pharmacology

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