dc-based immunotherapy combined with low-dose methotrexate effective in the treatment of advanced cia in mice
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2015
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Abstract
We have previously demonstrated that semimature dendritic cell- (smDC-) based immunotherapy is effective for the treatment of collagen-induced arthritis (CIA) prior to disease onset. In the present study, we examined the efficacy of combination therapy with smDCs and methotrexate (MTX) in advanced CIA with a score of 2-3. Combination therapy with low-dose MTX and type II collagen- (CII-) pulsed smDCs (CII-smDCs) was more effective in inhibiting disease progression than high or low-dose MTX alone or a combination of high dose MTX and CII-smDCs. The effect of CII-smDCs alone was also comparable to the combination therapy. CD4+Foxp3+ Treg populations and IL-10 secretion markedly increased, and CII-specific autoreactive T cells decreased in mice treated with CII-smDCs alone or in combination with MTX. Combination therapy reduced the secretion of interferon-γ (IFN-γ) and IL-17 with little influence on the IL-4 secretion in the mixed leukocyte reaction. These results imply that the combination therapy with low-dose MTX and smDCs is effective in controlling advanced CIA by enhancing Treg population and suppresses antigen-specific Th1/Th17 immunity, rather than initiating Th1 to Th2 immune deviation. Our findings provide a better understanding of the DC therapy in combination with MTX for the treatment of patients with rheumatoid arthritis (RA).
| Reference Key |
park2015journaldc-based
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|---|---|
| Authors | ;Jun-Eui Park;Jinah Jang;Ji-Hye Choi;Mi-sun Kang;Yun-Ju Woo;Young-Rim Seong;Chan-Bum Choi;Hye-Soon Lee;Sang-Cheol Bae;Yong-Soo Bae |
| Journal | journal of photochemistry and photobiology b, biology |
| Year | 2015 |
| DOI |
10.1155/2015/834085
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| URL | |
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