wading pools and fading memories – place navigation in transgenic mouse models of alzheimer’s disease

Clicks: 176
ID: 251593
2012
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
The Morris swim navigation task (‘water maze’) has been a primary research tools to assess hippocampal delpendent spatial learning and memory is rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious process, but nowadays there are more studies performed with the Morris swim task in mice than in rats. The task has proved to be particularly useful in demonstrating age-related memory impairment in transgenic mouse models of Alzheimer’s disease. This review focuses on task details that are most relevant for its application to mouse studies in general and characteristic patterns of impaired performance in Alzheimer model mice as compared with rodents sustaining hippocampal lesions.
Reference Key
etanila2012frontierswading Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Heikki eTanila
Journal Frontiers in chemistry
Year 2012
DOI
10.3389/fnagi.2012.00011
URL
http://journal.frontiersin.org/Journal/10.3389/fnagi.2012.00011/full
Keywords
spatial memory neuropsychiatry biological psychiatry tauneurosciences

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.